Epstein-Barr virus (EBV) is known to be a causative agent of hemophagocytic lymphohistiocytosis (HLH). To investigate association of apoptosis in the pathogenesis of EBV-associated HLH, the serum EBV loads, and serum concentrations of soluble tumor necrosis factor receptor 1 (sTNF-R1), soluble Fas l
Demonstration of type II latency in T lymphocytes of Epstein–Barr Virus-associated hemophagocytic lymphohistiocytosis
✍ Scribed by Yoshinori Ito; Yoshiki Kawamura; Seiko Iwata; Jun-ichi Kawada; Tetsushi Yoshikawa; Hiroshi Kimura
- Book ID
- 115560707
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 158 KB
- Volume
- 60
- Category
- Article
- ISSN
- 1545-5009
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## Abstract Expression of different panels of latent gene transcripts is controlled by usage of three distinct Epstein‐Barr virus (EBV) nuclear antigen (EBNA) promoters (Wp, Cp, and Qp). EBV‐associated hemophagocytic syndrome, which is often a fatal disease and generally occurs after primary EBV in
## BACKGROUND. Although familial hemophagocytic lymphohistiocytosis (FHL) has been considered a T-cell disorder, to the authors' knowledge there are no previous reports on the clonal basis of FHL. In the current study the authors analyzed the clonality of T-cells in two FHL patients at the time of