✦ LIBER ✦

Clonal change of infiltrating T-cells in children with familial hemophagocytic lymphohistiocytosis : Possible association with Epstein–Barr virus infection

✍ Scribed by Eiichi Ishii; Nobuhiro Kimura; Koji Kato; Masahiro Sako; Mitsuyuki Nagano; Atsuko Nakagawa; Takayuki Okamura; Hideto Yamaguchi; Keisei Kawa; Toshiro Hara

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 227 KB
Volume: 85
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19990401)85:7<1636::aid-cncr28>3.0.co;2-x

No coin nor oath required. For personal study only.

✦ Synopsis

BACKGROUND.

Although familial hemophagocytic lymphohistiocytosis (FHL) has been considered a T-cell disorder, to the authors' knowledge there are no previous reports on the clonal basis of FHL. In the current study the authors analyzed the clonality of T-cells in two FHL patients at the time of disease onset and at disease progression.