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Evaluation of apoptosis in Epstein–Barr virus-associated hemophagocytic lymphohistiocytosis

✍ Scribed by Jun-ichi Kawada; Hiroshi Kimura; Yukiko Shibata; Shinya Hara; Yo Hoshino; Seiji Kojima; Kazuo Nishikawa; Tsuneo Morishima

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
146 KB
Volume
78
Category
Article
ISSN
0146-6615

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✦ Synopsis

Epstein-Barr virus (EBV) is known to be a causative agent of hemophagocytic lymphohistiocytosis (HLH). To investigate association of apoptosis in the pathogenesis of EBV-associated HLH, the serum EBV loads, and serum concentrations of soluble tumor necrosis factor receptor 1 (sTNF-R1), soluble Fas ligand, and cytochrome c were examined in 15 patients with EBVassociated HLH and 24 patients with infectious mononucleosis (IM). Levels of sTNF-R1 are known to reflect the biological activity of TNF-a and cytochrome c is a specific marker of apoptosis. EBV loads, and concentrations of sTNF-R1 and cytochrome c were significantly higher in patients with EBV-associated HLH than in patients with IM. On the other hand, there were no statistically significant differences in the concentrations of soluble Fas ligand. In patients with EBVassociated HLH, EBV loads, concentrations of sTNF-R1, and cytochrome c were correlated with each other. These results suggest that apoptosis, which is dependent on the EBV load and could be mediated by TNF-a, plays a major role in the pathophysiology of EBV-associated HLH.

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