Demonstration of “naturally occurring mitochondrial antibodies” in family members of patients with primary biliary cirrhosis
✍ Scribed by Reinhild Klein; Prof. Dr. Peter A. Berg
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 720 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0270-9139
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## Abstract The association between celiac disease (CD) and primary biliary cirrhosis (PBC) is well documented in medical literature; however, a high frequency of false positive results of the anti‐transglutaminase (anti‐tTG) test has been reported in patients with PBC. To verify if the positive re
Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disorder that can progress to cirrhosis, shortening life expectancy. PBC patients are often asymptomatic, present with biochemical cholestasis, and test positive (>90%) for antimitochondrial antibodies (AMAs) in serum. Although AMA posit
Primary biliary cirrhosis (PBC) is a disease that typically affects middle-aged women and is characterized by progressive intrahepatic cholestasis which leads ultimately to cirrhosis, portal hypertension and hepatocellular failure (1). The underlying histopathological lesion in PBC is a chronic, non
Antimitochondrial antibodies are characteristically detected in sera of patients with primary biliary cirrhosis. The antigens to which the antimitochondrial antibodies in primary biliary cirrhosis sera react have been located in the mitochondrial inner membrane. We have reported on four mitochondria