𝔖 Bobbio Scriptorium
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Delivery of immunostimulatory monoclonal antibodies by encapsulated hybridoma cells

✍ Scribed by Juan Dubrot; Aitziber Portero; Gorka Orive; Rosa María Hernández; Asis Palazón; Ana Rouzaut; Jose L. Perez-Gracia; Sandra Hervás-Stubbs; Jose Luis Pedraz; Ignacio Melero

Book ID
105967794
Publisher
Springer-Verlag
Year
2010
Tongue
English
Weight
900 KB
Volume
59
Category
Article
ISSN
0340-7004

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An attempt has been made to mathematically describe and analyze monoclonal antibody (MAB) productivity of hybridoma cells, with particular emphasis on continuous cultures under unsteady-state conditions. A simple and unstructured general kinetic model that takes account of productivity loss during l