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Improvement of Monoclonal Antibody Production in Hybridoma Cells by Dimethyl Sulfoxide

✍ Scribed by Wai Lam W. Ling; Liang Deng; Joseph Lepore; Collette Cutler; Susan Cannon-Carlson; Yan Wang; Marcio Voloch

Book ID
109386488
Publisher
American Institute of Chemical Engineers
Year
2003
Tongue
English
Weight
111 KB
Volume
19
Category
Article
ISSN
8756-7938

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An attempt has been made to mathematically describe and analyze monoclonal antibody (MAB) productivity of hybridoma cells, with particular emphasis on continuous cultures under unsteady-state conditions. A simple and unstructured general kinetic model that takes account of productivity loss during l