Deletion mapping and candidate gene analysis of chromosome 17 in primitive neuroectodermal tumors of the CNS
β Scribed by Jaclyn Biegel; Annette Parmiter; Ignacio Rodriguez; Krzyzstof Mazuruk; Gerald Chader; Irene Slavc
- Book ID
- 113253817
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 144 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0165-4608
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A series of 18 primitive neuroectodermal tumors (PNETs), the most common malignant central nervous system tumors of childhood. were analyzed with the recently developed approach of comparative genomic hybridization (CGH). In five cases, in which only small amounts of DNA were available, universal po
Loss of heterozygosity (LOH) on chromosome arm 17p is the most common genetic aberration in childhood primitive neuroectodermal tumors (PNETs). To determine the frequency and extent of 17p deletions, 29 loci on 17p were investigated in 24 tumors by using restriction fragment length polymorphism (RFL
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