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Chromosome arm 17p deletion analysis reveals molecular genetic heterogeneity in supratentorial and infratentorial primitive neuroectodermal tumors of the central nervous system

✍ Scribed by Margaret E. Burnett; Eileen C. White; Sharon Sih; Markus S. von Haken; Philip H. Cogen

Book ID: 114136158
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 698 KB
Volume: 97
Category: Article
ISSN: 0165-4608
DOI: 10.1016/s0165-4608(96)00319-6

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Loss of heterozygosity (LOH) on chromosome arm 17p is the most common genetic aberration in childhood primitive neuroectodermal tumors (PNETs). To determine the frequency and extent of 17p deletions, 29 loci on 17p were investigated in 24 tumors by using restriction fragment length polymorphism (RFL