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Deletion and amplification of DNA sequences in melanin-negative variants of Streptomyces reticuli

✍ Scribed by Schrempf, Hildgund

Publisher
Springer
Year
1983
Tongue
English
Weight
524 KB
Volume
189
Category
Article
ISSN
0026-8925

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✦ Synopsis

The sporulating wild type of Streptomyces reticuli produces the pigment melanin. Though the ability to synthesize tyrosinase is frequently lost, it was demonstrated, that the structural gene coding for this enzyme is not located on the extrachromosomal DNA of the wild type strain or melanin-positive variants. Melanin negative variants were found to have lost this gene and to contain amplified nucleotide sequences within their genomes.

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