## Abstract The syntheses of [19,20‐^3^H~2~]‐ and [3,3,4,4,5,5,6,6‐^2^H~8~]‐(17__R__)‐ 17,20‐dimethyl‐7‐thiaprostaglandin E~1~ methyl esters (3 and 5) are described. The di‐tritiated compound 3 was prepared from its protected (__Z__)‐Δ ^19^‐precursor (21) __via__ catalytic reduction with tritium ga
Dehydration and epimerization of 7-thiaprostaglandin E1 analogues
✍ Scribed by Takeo Kawaguchi; Yoshiki Suzuki
- Book ID
- 102407750
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 271 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0022-3549
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📜 SIMILAR VOLUMES
The dehydration of the P-hydroxycyclopentanone, 11,16dihydroxy-16-methyl-9-oxo-13-trans-protenoic acid methyl ester, an analogue of prostaglandin El, proceeds with acid catalysis (pH < 3), by uncatalyzed routes (pH N 4 and N 7), and with base catalysis (pH N 5-6 and > 8). Deuterium from the solvent
## Abstract The syntheses of [7‐^2^H]‐, [7‐^3^H]‐, and [2,2,3,3,4,4‐^2^H~6~]‐(16__S__)‐15‐deoxy‐16‐ hydroxy‐16‐methyl‐5‐thiaprostaglandin E~1~ methyl ester (2, 3, and 4) are described. Both 7‐labeled compounds, 2 and 3, were prepared from the Δ^7^‐precursor (11) by treatment with __in‐situ__ genera