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Syntheses of 3H- and 2H-labeled (17R)-17,20-dimethyl-7-thiaprostaglandin E1 methyl ester

✍ Scribed by Toshio Tanaka; Kiyoshi Bannai; Kenji Manabe; Seizi Kurozumi

Book ID
102901147
Publisher
John Wiley and Sons
Year
1991
Tongue
French
Weight
662 KB
Volume
29
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The syntheses of [19,20‐^3^H~2~]‐ and [3,3,4,4,5,5,6,6‐^2^H~8~]‐(17__R__)‐ 17,20‐dimethyl‐7‐thiaprostaglandin E~1~ methyl esters (3 and 5) are described. The di‐tritiated compound 3 was prepared from its protected (Z)‐Δ ^19^‐precursor (21) via catalytic reduction with tritium gas having a specific activity of 49 Ci / mmol. The octa‐deuterated compound 5 was prepared from tetrahydrofuran‐d~8~.

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