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Degradation of missense mutant β-galactosidase proteins in Escherichia coli K-12

✍ Scribed by Bergquist, P. L. ;Truman, Penelope

Publisher
Springer
Year
1978
Tongue
English
Weight
304 KB
Volume
164
Category
Article
ISSN
0026-8925

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✦ Synopsis

Ten out of 43 missense mutations in the lacZ gene of Escherchia coli gave rise to polypeptide chains that were degraded in vivo. While many of the mutants appeared to be fully or partially CRM-, there appeared to be no obvious correlation between degradation, map position, altered subunit association and the half-life of the mutant proteins.

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