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Degradation of abnormal proteins in heLa cells

✍ Scribed by Klavs B. Hendil

Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
524 KB
Volume
87
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

The experiments show that abnormal proteins are degraded faster than normal ones in HeLa cells. Among the fragmentary proteins made in the presence of puromycin, those with low molecular weight are least stable. Proteins made after incubation with 5‐fluorouracil or in the presence of some amino acid analogues are also unstable. Breakdown of proteins made in the presence or absence of puromycin is nearly unaffected by cycloheximide and is independent of pH between 7 and 8.

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