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Defining regions of loss of heterozygosity of 16q in breast cancer cell lines

✍ Scribed by David F. Callen; Joanne Crawford; Cathy Derwas; Anne-Marie Cleton-Jansen; Cees J. Cornelisse; Elizabeth Baker


Book ID
114135229
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
244 KB
Volume
133
Category
Article
ISSN
0165-4608

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One of the main genetic abnormalities associated with breast carcinogenesis is the loss of genetic material from chromosome arm 16q. Different groups have identified two regions (16q22.1 and 16q24-ter) that are frequently deleted in primary tumors, suggesting the presence of tumor suppressor genes i