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Defective signal transduction in CD4−CD8− T cells of lpr mice

✍ Scribed by Frances Stafford-Brady; Eiji Sugiyama; Dwight R. Robinson; Man-Sun Sy; Joseph V. Bonventre; Edward T.H. Yeh


Book ID
113134407
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
590 KB
Volume
123
Category
Article
ISSN
0008-8749

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MRL/lpr CD4−CD8− and CD8+ T cells, respe
✍ Karim Benihoud; Danielle Bonardelle; Pierre Bobé; Nicole Kiger 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 701 KB

Autoimmune-prone MRL/lpr mice, homozygous for the lpr mutation, exhibit defective apoptosis and develop generalized lymphoproliferation with the accumulation of a double-negative (DN: CD4- CD8-) T cell population. The capacity of lpr T lymphocytes to effectuate Fas- and perforin-mediated cytotoxicit