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Defective DNA methylation and CD70 overexpression in CD4+ T cells in MRL/lpr lupus-prone mice

✍ Scribed by Amr H. Sawalha; Matlock Jeffries


Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
254 KB
Volume
37
Category
Article
ISSN
0014-2980

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✍ Kurt Oelke; Qianjin Lu; Derek Richardson; Ailing Wu; Chun Deng; Samir Hanash; Br 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 149 KB

## Abstract ## Objective Generalized DNA hypomethylation contributes to altered T cell function and gene expression in systemic lupus erythematosus (SLE). Some of the overexpressed genes participate in the disease process, but the full repertoire of genes affected is unknown. Methylation‐sensitive