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Defective mitochondrial disulfide relay system, altered mitochondrial morphology and function in Huntington's disease

✍ Scribed by Napoli, E.; Wong, S.; Hung, C.; Ross-Inta, C.; Bomdica, P.; Giulivi, C.


Book ID
119962080
Publisher
Oxford University Press
Year
2012
Tongue
English
Weight
389 KB
Volume
22
Category
Article
ISSN
0964-6906

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## Abstract Huntington's disease (HD) is caused by an abnormally expanded CAG repeat in the __IT__‐__15__ gene, which encodes a widely expressed protein called huntingtin. Abnormalities of mitochondrial respiratory chain function, specifically complex II/III, have been identified in HD striatum and