𝔖 Bobbio Scriptorium
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Defective Interfering Viruses

✍ Scribed by Huang, A S

Book ID
115485113
Publisher
Annual Reviews
Year
1973
Tongue
English
Weight
554 KB
Volume
27
Category
Article
ISSN
0066-4227

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## Abstract Defective interfering (DI) virus is simply defined as a spontaneously generated virus mutant from which a critical portion of the virus genome has been deleted. At least one essential gene of the virus is deleted, either in its entirety, or sufficiently to make it non‐functional. The re

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Defective-interfering (DI) viruses arise spontaneously by deletion mutations. The shortened genomes of the DI particles cannot replicate unless they coinfect a cell with a wild-type virus. Upon coinfection, the DI genome replicates more quickly and outcompetes the wild type. The coinfected cell prod