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Defective Interfering RNAs: Foes of Viruses and Friends of Virologists

โœ Scribed by Pathak, Kunj B.; Nagy, Peter D.


Book ID
118036478
Publisher
MDPI AG
Year
2009
Tongue
English
Weight
487 KB
Volume
1
Category
Article
ISSN
1999-4915

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Defective-interfering (DI) viruses arise spontaneously by deletion mutations. The shortened genomes of the DI particles cannot replicate unless they coinfect a cell with a wild-type virus. Upon coinfection, the DI genome replicates more quickly and outcompetes the wild type. The coinfected cell prod