Defective class II transactivator expression in a B lymphoma cell line
✍ Scribed by Prod'homme, T; Drénou, B; De Ruyffelaere, C; Barbieri, G; Wiszniewski, W; Bastard, C; Charron, D; Alcaide-Loridan, C
- Book ID
- 110055841
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 262 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0887-6924
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract We first classified 12 malignant glioma cell lines into three different groups (types 1–3) with respect to major histocompatibility complex (MHC) class II expression and analyzed each group based on the different expression status of the class II transactivator (CIITA) gene. Glioma type
The major histocompatibility (MHC) class II genes encode cell surface proteins that bind antigenic peptide for presentation to T-cells. The class II proteins are expressed constitutively on B-cells and EBV-transformed B-cells, and are inducible by IFN-y on a wide variety of cell types. Retinoblastom