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Kinase inhibitors abrogate IFN-γ-induced class II transactivator and class II MHC gene expression in astroglioma cell lines

✍ Scribed by Nicholas J Van Wagoner; George M O'Keefe; Etty N Benveniste


Book ID
117337676
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
801 KB
Volume
85
Category
Article
ISSN
0165-5728

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The major histocompatibility (MHC) class II genes encode cell surface proteins that bind antigenic peptide for presentation to T-cells. The class II proteins are expressed constitutively on B-cells and EBV-transformed B-cells, and are inducible by IFN-y on a wide variety of cell types. Retinoblastom