## Abstract Downregulation of major histocompatibility complex (MHC) molecules by tumor cells impairs cellular immune recognition and contributes to inefficient cell‐mediated tumor eradication. Low or lack of expression of MHC molecules is frequently observed in early developmental or embryonically
Isolation of a B-cell-specific promoter for the human class II transactivator
✍ Scribed by Ana-Maria Lennon; Catherine Ottone; Gildas Rigaud; Larry L. Deaven; Jon Longmire; Marc Fellous; Rosa Bono; C. Alcaïde-Loridan
- Publisher
- Springer-Verlag
- Year
- 1997
- Tongue
- English
- Weight
- 302 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0093-7711
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In the normal central nervous system (CNS) expression of MHC class II is minimal, but has been found to be highly up-regulated on microglia cells in experimental autoimmune encephalitis (EAE). Here we used the EAE model to examine the regulation of expression of the class II transactivator (CIITA),
## Abstract In this study the genetic control of major histocompatibility complex (MHC) class II gene expression during the transition from B cell to plasma cell has been analyzed. Class II molecules are not expressed in plasma cells because of an active suppression resulting in the abrogation of c