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Defective calcium homeostasis in the cerebellum in a mouse model of Niemann–Pick A disease

✍ Scribed by Luba Ginzburg; Anthony H. Futerman

Book ID: 111179275
Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 583 KB
Volume: 95
Category: Article
ISSN: 0022-3042
DOI: 10.1111/j.1471-4159.2005.03534.x

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## Abstract The BALB/c mouse model of Niemann‐Pick type C (NPC) disease exhibits neuropathological similarities to the human condition. There is an age‐related cerebral atrophy, demyelination of the corpus callosum, and degeneration of cerebellar Purkinje cells in the NPC mouse. In human NPC, many