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Defective activation and survival of T cells lacking the Ets-1 transcription factor

✍ Scribed by Muthusamy, Natarajan; Barton, Kevin; Leiden, Jeffrey M.

Book ID
109794244
Publisher
Nature Publishing Group
Year
1995
Tongue
English
Weight
865 KB
Volume
377
Category
Article
ISSN
0028-0836

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## Abstract Transcription factor Ets‐1 is induced in endothelial cells (ECs) by angiogenic factors, and promotes angiogenesis by inducing angiogenesis‐related genes such as MMPs and integrin Ξ²3. Here, we examined the effect of Ets‐1 on apoptosis in ECs. Overexpression of Ets‐1 in human umbilical ve