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HER2/Neu-mediated activation of the ETS transcription factor ER81 and its target gene MMP-1

โœ Scribed by Bosc, Denis G; Goueli, Basem S; Janknecht, Ralf


Book ID
110066060
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
321 KB
Volume
20
Category
Article
ISSN
0950-9232

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Regulation of Her2/neu promoter activity
โœ Denis G. Bosc; Ralf Janknecht ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 266 KB

Overexpression of the HER2/Neu receptor is correlated to a poor prognosis in tumor patients and leads to stimulation of mitogen-activated protein kinase (MAPK) signaling pathways, which in turn activate transcription factors, such as the ETS protein ER81. Here, we have analyzed whether, on the other