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Decreased tryptophan catabolism by placental indoleamine 2,3-dioxygenase in preeclampsia

✍ Scribed by Yoshiki Kudo; C.A.R. Boyd; Ian L. Sargent; Christopher W.G. Redman

Book ID
114488182
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
281 KB
Volume
188
Category
Article
ISSN
1097-6868

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## Abstract The first and rate‐limiting step of the kynurenine pathway, in which tryptophan (Trp) is converted to __N__‐formylkynurenine is catalyzed by two heme‐containing proteins, Indoleamine 2,3‐dioxygenase (IDO), and Tryptophan 2,3‐dioxygenase (TDO). In mammals, TDO is found exclusively in liv