Decreased dopamine transporters with age in healthy human subjects

✍ Scribed by Dr. N. D. Volkow; J. S. Fowler; G. J. Wang; J. Logan; D. Schlyer; R. MacGregor; R. Hitzemann; A. P. Wolf

• Book ID: 101468181
• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 354 KB
• Volume: 36
• Category: Article
• ISSN: 0364-5134
• DOI: 10.1002/ana.410360218

✦ Synopsis

The effects of aging on brain dopamine transporters was evaluated in 26 healthy male volunteers (age range, 2 1-63 years) using positron emission tomography and ["C}cocaine. The ratio of the distribution volume for ["CIcocaine in basal ganglia to that in cerebellum was used as a model parameter for dopamine transporter availability and showed a significant negative correlation with age (T = 0.65, p < 0.0005). This results document an age-related decline in dopamine transporters in healthy individuals.