Striatal dopamine transporters correlate with simple reaction time in elderly subjects
β Scribed by Christopher H. van Dyck; Robert A. Avery; Martha G. MacAvoy; Kenneth L. Marek; Donald M. Quinlan; Ronald M. Baldwin; John P. Seibyl; Robert B. Innis; Amy F.T. Arnsten
- Book ID
- 116781091
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 230 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0197-4580
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## Abstract We studied whether the ^123^IβFPβCIT uptake in the striatum correlates with depressive symptoms and cognitive performance in patients with Parkinson's disease (PD). Twenty patients with PD without major depression and/or dementia (mean age 61.7 Β± 12.7 years) underwent the ^123^IβFPβCIT
The time course of the loss in presynaptic dopamine transporters (DAT) and of the increase in postsynaptic dopamine D2 receptors (D2R) was studied in a rat model of Parkinson's disease. For this, in vitro autoradiographic experiments were performed in the striatum using (E)-N-(3-iodoprop-2-enyl)-2be