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Decreased collagen-induced arthritis severity and adaptive immunity in MKK-6–deficient mice

✍ Scribed by Deepa Hammaker; Katharyn Topolewski; Meghan Edgar; Toshio Yoshizawa; Akihisa Fukushima; David L. Boyle; Esther Cory Burak; Robert L. Sah; Gary S. Firestein


Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
271 KB
Volume
64
Category
Article
ISSN
0004-3591

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## Abstract ## Objective To examine the influence of superoxide on the severity of collagen‐induced arthritis (CIA) in mice. ## Methods CIA was induced in DBA/1J mice lacking the extracellular superoxide dismutase (EC‐SOD) gene (knockout [KO]) and in normal DBA/1J mice (wild‐type [WT]). ## Resu