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Delayed onset and reduced severity of collagen-induced arthritis in interleukin-6–deficient mice

✍ Scribed by Mitsuko Sasai; Yukihiko Saeki; Shiro Ohshima; Katsuhiro Nishioka; Toru Mima; Toshio Tanaka; Yoshinori Katada; Kazuyuki Yoshizaki; Masaki Suemura; Tadamitsu Kishimoto

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
178 KB
Volume
42
Category
Article
ISSN
0004-3591

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## Abstract ## Objective To examine the influence of superoxide on the severity of collagen‐induced arthritis (CIA) in mice. ## Methods CIA was induced in DBA/1J mice lacking the extracellular superoxide dismutase (EC‐SOD) gene (knockout [KO]) and in normal DBA/1J mice (wild‐type [WT]). ## Resu