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Decreased cisplatin uptake by resistant L1210 leukemia cells

โœ Scribed by Hromas, Robert A.; North, James A.; Burns, C.Patrick

Book ID
122834261
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
361 KB
Volume
36
Category
Article
ISSN
0304-3835

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Methionine-auxotrophic L1210 cells were used to study the effect of methotrexate (MTX) on methionine uptake and metabolism. MTX was shown to inhibit amino acid transport systems and cause a decrease of methionine uptake into L1210 cells. Conversely, a nonmetabolizable amino acid analogue reduced MTX