Investigations on the mechanisms of methotrexate resistance in a cisplatin-resistant L1210 murine leukemia cell subline
β Scribed by Diana H. Wroblewski; Alok Bhushan; Yongzhi Xuan; Bradford T. Brinton; Thomas R. Tritton; Miles P. Hacker
- Publisher
- Springer
- Year
- 1996
- Tongue
- English
- Weight
- 354 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0344-5704
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The effect of levamisole (LMS) on T-cell-mediated antitumor immunity was examined in adult and aged mice hyperimmune to L1210 leukemia. The immune resistance of aged mice was depressed compared with that of adult mice, which almost completely rejected 5 X 10(7) L1210 cells inoculated IP. A significa
## Cells res&tant to methotrexate (LI210/R7A) and possessing an increased level of dihydrofolate reductase due to gene amplification can be detected by the technique of flow cytofluorimetry using a new fluorescent derivative of methotrexate (F-MTX) based on a putrescine linker. Comparative studies o