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Debrisoquine oxidation polymorphism in a Tasmanian population

✍ Scribed by M. E. Veronese; S. McLean

Publisher: Springer
Year: 1991
Tongue: English
Weight: 389 KB
Volume: 40
Category: Article
ISSN: 0031-6970
DOI: 10.1007/bf00315235

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✦ Synopsis

The debrisoquine hydroxylation phenotype was studied in 152 unselected healthy Tasmanian subjects, who were mostly Caucasians of British ancestry. Following a 10 mg oral dose of debrisoquine (D), the ratio of D/4-hydroxydebrisoquine excreted in 8-h urine (metabolic ratio, MR) was determined. MR values were bimodally distributed. Thirteen subjects (8.6%) had MR values from 13.8 to 93.3 and were considered to be poor metabolisers of D, while the others were extensive metabolisers with MR values of 0.04 to 5.4. The D hydroxylation phenotype was not associated with sex. These findings confirm the constancy of D polymorphism in a Caucasian population even after migration to another country.

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