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Genetically determined sparteine oxidation polymorphism in a Polish population

✍ Scribed by K. Orzechowska-Juzwenko; J. Pawlik; P. Niewiński; P. Milejski; J. Dembowski; J. Turek; A. Goździk; L. Swiebodzki; Z. Hora

Publisher
Springer
Year
1994
Tongue
English
Weight
259 KB
Volume
46
Category
Article
ISSN
0031-6970

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✦ Synopsis

The genetic oxidation polymorphism was determined in 160 healthy Polish volunteers from the southwest of Poland (Wroctaw region), using sparteine as a model drug. The results of a Polish population study revealed a bimodal distribution of the sparteine metabolic ratio and showed the existence of two oxidation phenotypes designated as extensive and poor metabolizers. The frequency of poor metabolizers in our study (8.8 %) compares well with most results of poor oxidation metabolizers in Caucasian populations.

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