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Ifosfamide plasma clearance in relation to polymorphic debrisoquine oxidation

✍ Scribed by Philip A. Philip; Lionel D. Lewis; Christopher A. James; Howard J. Rogers

Publisher
Springer
Year
1988
Tongue
English
Weight
324 KB
Volume
22
Category
Article
ISSN
0344-5704

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✦ Synopsis

Ifosfamide (IF) pharmacokinetics and the plasma (NBP)-alkylating activity were determined in 33 patients with different tumours after the administration of IF as single-agent chemotherapy. All subjects had been phenotyped for debrisoquine oxidation. There is a lack of correlation between the debrisoquine metabolic ratio (DMR) and either the total plasma clearance of IF (CLIF) or the AUC of the plasma NBP-alkylating activity.

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