Debrisoquine and mephenytoin oxidation in Sinhalese: a population study.
β Scribed by K Weerasuriya; RL Jayakody; CA Smith; CR Wolf; GT Tucker; MS Lennard
- Book ID
- 117945646
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 755 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0306-5251
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European data on the polymorphic metabolism of debrisoquine, sparteine, dextromethorphan and mephenytoin have been collected. No significant difference in phenotype frequencies was found between the separate series for debrisoquine, sparteine and dextromethorphan, which supports the claim that these
The debrisoquine hydroxylation phenotype was studied in 152 unselected healthy Tasmanian subjects, who were mostly Caucasians of British ancestry. Following a 10 mg oral dose of debrisoquine (D), the ratio of D/4-hydroxydebrisoquine excreted in 8-h urine (metabolic ratio, MR) was determined. MR valu