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Deamidation of Asparagine Residues in a Recombinant Serine Hydroxymethyltransferase

✍ Scribed by Martino L. di Salvo; Sonia Delle Fratte; Bruno Maras; Francesco Bossa; H.Tonie Wright; Verne Schirch


Book ID
115567921
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
299 KB
Volume
372
Category
Article
ISSN
0003-9861

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## Abstract One of the most frequent modifications in proteins and peptides is the deamidation of asparagine, a spontaneous non‐enzymatic reaction leading to a mixture of L,D‐succinimidyl, L,D‐aspartyl, and L,D‐isoaspartyl forms, with L‐isoaspartyl dominating. Spontaneous isomerization of L‐Asp yie