Thymocytes co-expressing the CD4 and CD8 co-receptors differentiate into mature T cells that express either CD4 or CD8 and have helper or cytotoxic functions, respectively. Recent studies indicate that commitment to the CD4+ or CD8+ lineages occurs stochastically, but retention of the appropriate co
β¦ LIBER β¦
Deadbeat neighbors influence thymocyte lineage commitment
β Scribed by Fink, Pamela J
- Book ID
- 109921571
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 419 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1529-2908
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## Abstract CD4βpositive helper T cells and CD8βpositive cytotoxic T cells comprise the majority of T lymphocytes present in secondary lymphoid organs and are essential for acquired immunity. These two populations are derived from common precursors in the thymus and selected through interaction bet
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