𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Thymocyte lineage commitment: is it instructed to stochastic?

✍ Scribed by Craig B. Davis; Dan R. Littman

Book ID
103973072
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
892 KB
Volume
6
Category
Article
ISSN
0952-7915

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✦ Synopsis

Thymocytes co-expressing the CD4 and CD8 co-receptors differentiate into mature T cells that express either CD4 or CD8 and have helper or cytotoxic functions, respectively. Recent studies indicate that commitment to the CD4+ or CD8+ lineages occurs stochastically, but retention of the appropriate co-receptor is required to complete development.

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