𝔖 Bobbio Scriptorium
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Introduction: Commitment to CD4 and CD8 lineages—stochastic or instructive?

✍ Scribed by Ellen Robey

Book ID
115647758
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
115 KB
Volume
6
Category
Article
ISSN
1044-5323

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MHC specificity in positive selection is a major determinant in the CD4/CD8 T cell lineage decision. Previous studies support the view that quantitative differences in T cell receptor (TCR) signaling in immature CD4 + CD8 + double positive thymocytes leads to an instructive bias in CD4/CD8 T cell li