✦ LIBER ✦

DCC gene alteration in human endometrial carcinomas

✍ Scribed by Tomonao Gima; Hidenori Kato; Tsuyoshi Honda; Toshiro Imamura; Takehiko Sasazuki; Norio Wake

Publisher: John Wiley and Sons
Year: 1994
Tongue: French
Weight: 951 KB
Volume: 57
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910570407

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The present study was undertaken to define the gene(s) of importance on the long arm of chromosome 18 (chromosome 18q) in endometrial carcinomas. We analyzed loss of heterozygosity (LOH) at 3 loci on chromosome 18q and DCC gene expression by the reverse‐transcriptase/polymerase chain reaction (RT‐PCR) method. Among 61 tumors that were informative, 16 (26%), estimated to be a minimum number, showed allelic losses at one or more chromosome 18q loci. Deletions in these tumors possibly involved the region within or near the chromosome 18q 21.3 band where the DCC gene was localized. Moreover, the incidence of altered DCC mRNA expression was high in these tumors. Appropriate transcription was lost in 5 of 7 (71%) carcinoma cell lines in addition to 14 of 28 (50%) surgically resected tumors. Histopathological differentiation and clinical stage of disease were not related to LOH frequency or to DCC mRNA expression. These results suggest that the target for allelic loss on chromosome 18q seen in endometrial carcinomas is the DCC gene, and that inactivation of this gene may be critical for the development of most endometrial carcinomas. © 1994 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Involvement of p53 gene mutations in hum

Involvement of p53 gene mutations in human endometrial carcinomas

✍ Tsuyoshi Honda; Hidenori Kato; Toshiro Imamura; Tomonao Gima; Jun-Ichi Nishida; 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 1019 KB

Mutations in the p53 gene are associated with a wide variety of human malignancies. Point mutation in one allele and loss of the remaining one generally lead to inactivation of p53 protein. A high frequency of allelic losses corresponding to the I7p 13.3 region that contained the p53 gene sequence

p53 gene mutations in human endometrial

p53 gene mutations in human endometrial carcinoma

✍ John I. Risinger; Georgette A. Dent; Diane Ignar-Trowbridge; John A. McLachlan; 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 403 KB

## Abstract Although carcinoma of the uterine endometrium is the most frequently diagnosed malignancy of the female reproductive tract, the molecular genetic features of this tumor have yet to be described in significant detail. Since mutations of the __p53__ tumor suppressor gene are the single mo

Chromosomal deletions and K-ras gene mut

Chromosomal deletions and K-ras gene mutations in human endometrial carcinomas

✍ Toshiro Imamura; Takahiro Arima; Hidenori Kato; Shingo Miyamoto; Takehiko Sasazu 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 French ⚖ 920 KB

## Abstract Forty‐two endometrial carcinomas of various stages of progression were analyzed to search for loss of chromosomal regions and for point mutations of __ras__ genes and amplification of Int‐2 gene. This approach is particularly favorable for observation of genetic events and their signifi

fhit alterations in endometrial carcinom

fhit alterations in endometrial carcinoma and hyperplasia

✍ Keiichiro Ozaki; Takayuki Enomoto; Kiyoshi Yoshino; Sun Hongbo; Takafumi Nakamur 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 747 KB

The fhit (fragile histidine triad) gene on chromosome 3p14.2 is a candidate tumour-suppressor gene; its abnormal transcripts are detected in several human cancers. To define the role of the fhit gene in the development of endometrial cancer, we examined 39 endometrial carcinomas for the presence of

Analysis of oncogene alterations in huma

Analysis of oncogene alterations in human endometrial carcinoma: Prevalence of ras mutations

✍ Jeff Boyd; John I. Risinger 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 767 KB

The molecular genetics of human endometrial carcinoma have yet to be defined to any significant extent. Cell lines from 11 endometrial carcinomas were examined for alterations in proto-oncogenes that might predictably be present, based on existing data from the better-characterized human carcinomas

Distinct sets of gene alterations in end

Distinct sets of gene alterations in endometrial carcinoma implicate alternate modes of tumorigenesis

✍ Anjila Koul; Roger Willén; Pär-Ola Bendahl; Mef Nilbert; Åke Borg 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 96 KB

## Abstract ## BACKGROUND Endometrial carcinomas seem to carry a different prognosis depending on the presence or absence of concomitant complex atypical hyperplasia (hyperplasia). The molecular genetic profile of these two pathogenetic types, based on the genes reportedly mutated in these cancers