𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Analysis of oncogene alterations in human endometrial carcinoma: Prevalence of ras mutations

✍ Scribed by Jeff Boyd; John I. Risinger

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
767 KB
Volume
4
Category
Article
ISSN
0899-1987

No coin nor oath required. For personal study only.

✦ Synopsis

The molecular genetics of human endometrial carcinoma have yet to be defined to any significant extent. Cell lines from 11 endometrial carcinomas were examined for alterations in proto-oncogenes that might predictably be present, based on existing data from the better-characterized human carcinomas of the uterine cervix, ovary, and breast. Codons 12, 13, and 61 of the Ha-ras, Ki-ras, and N-ras genes were examined for possible point mutations, and the c-erbB2/neu, c-myc, and epidermal growth factor receptor (EGFR) genes were examined for amplification or overexpression. Ras mutations were found in seven of 11 (64%) tumors, including three in codon 61 of Ha-ras (CAG----CAT) and four in codon 12 of Ki-ras (GGT----GAT in two and GGT----GTT in two). No evidence was found for amplification or overexpression of the c-erbB2 or EGFR genes in any tumor. One tumor contained amplified c-myc sequences and exhibited relative overexpression of c-myc. These data suggest that the amplification or overexpression of several proto-oncogenes frequently observed in other human gynecologic and breast tumors are not prevalent in endometrial carcinoma and that ras gene mutations are relatively common in this tumor type.

πŸ“œ SIMILAR VOLUMES

Prevalence of G-TO-T transversions among
Prevalence of G-TO-T transversions among K-ras oncogene mutations in human colorectal tumors in Yugoslavia
✍ NadeΕΎda UroΕ‘eviΔ‡; Aleksandar DujiΔ‡; Koviljka Krtolica; Andjelija Ε karo-MiliΔ‡; Sl πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 French βš– 961 KB

Human colorectal carcinoma tissue sampled from 37 patients, routinely graded into Dukes' stages A, B and C and histologically examined for the level of differentiation, were analyzed for the presence of point mutations in the K-ros oncogene. Seventeen cases out of the 37 analyzed were found to have

Comparative analysis of ras proto-oncoge
Comparative analysis of ras proto-oncogene mutations in selected mammalian tumors
✍ F. Watzinger; B. Mayr; R. Gamerith; C. Vetter; T. Lion πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 227 KB

## Abstract Point mutations within __ras__ proto‐oncogenes are frequently detected in human malignancies and in different types of experimentally induced tumors in animals. In contrast to findings in experimental animal models of carcinogenesis, little is known about the incidence of __ras__ mutati

Clinical application of K-ras oncogene m
Clinical application of K-ras oncogene mutations in pancreatic carcinoma: Detection of micrometastases
✍ Shuji Nomoto; Akimasa Nakao; Nobuhisa Ando; Shin Takeda; Yasushi Kasai; Soichiro πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 46 KB πŸ‘ 2 views

Pancreatic adenocarcinomas are known to have a high incidence of K-ras gene mutation. We summarize our efforts to detect micrometastases through a search for mutated K-ras oncogene in liver tissues, peritoneal washings, para-aortic lymph nodes, and perioperative peripheral blood. Two-stage polymeras

Involvement of p53 gene mutations in hum
Involvement of p53 gene mutations in human endometrial carcinomas
✍ Tsuyoshi Honda; Hidenori Kato; Toshiro Imamura; Tomonao Gima; Jun-Ichi Nishida; πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 French βš– 1019 KB

Mutations in the p53 gene are associated with a wide variety of human malignancies. Point mutation in one allele and loss of the remaining one generally lead to inactivation of p53 protein. A high frequency of allelic losses corresponding to the I7p 13.3 region that contained the p53 gene sequence