Daunorubicin attenuates tumor necrosis factor-α-induced biosynthesis of plasminogen activator inhibitor-1 in human umbilical vein endothelial cells
✍ Scribed by Shinji Soeda; Kenji Iwata; Yoshiko Hosoda; Hiroshi Shimeno
- Book ID
- 117350626
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 435 KB
- Volume
- 1538
- Category
- Article
- ISSN
- 0167-4889
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## Abstract Plasminogen activator inhibitor type 1 (PAI‐1), which plays a role in the development of atherosclerosis, is produced by endothelial cells following stimulation with various inflammatory cytokines such as tumor necrosis factor (TNF‐α). In the present study, we investigated the effects o
The effects were examined of baicalein on tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) production stimulated by interleukin-1␣ (IL-1) and tumour necrosis factor-␣ (TNF-␣) in cultured human vein umbilical endothelial cells (HUVECs). IL-1 and TNF-␣ increased