✦ LIBER ✦

Daunomycin-arachidonic acid complex as a potential new antitumor agent

✍ Scribed by T. Sasaki; Y. Tsukada; H. F. Deutsch; H. Hirai

Book ID: 104686958
Publisher: Springer
Year: 1984
Tongue: English
Weight: 326 KB
Volume: 13
Category: Article
ISSN: 0344-5704
DOI: 10.1007/bf00257117

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✦ Synopsis

A daunomycin-arachidonic acid complex (DM-C20:4) administered IV had a marked antitumor effect on the intraperitoneal growth of the AFP-producing hepatoma cell line, AH66. However, the daunomycin-arachidic acid (DM-C20:0) saturated fatty acid complex showed only the same antitumor effect on the AH66 cells as free daunomycin. It was demonstrated that the DM-C20:4 preparation maintained its chemical properties for some time in both plasma and liver homogenate.

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