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A new approach to the synthesis of substituted 4-imidazolidinones as potential antiviral and antitumor agents

✍ Scribed by Ahmed I. Khodair; Philippe Bertrand

Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 732 KB
Volume: 54
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(98)00170-7

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✦ Synopsis

5-((Z)-Arylidene)-2-((2-(E)-benzylidene)hydrazono)-4-imidazolidinones 7a-d and 5-((Z)arylidene)-2-((2-(E)-polyhydroxyalkylidene)hydrazono)-4-imidazolidinones lla-d to 15a-d were prepared from the reaction of 5-((Z)-arylidene)-2-methylmercaptohydantoins 3a-d with 2-(E)benzylidene hydrazone 6 or 2-(E)

-monosaccharides hydrazones 9a-e, which in turn were prepared by condensation of benzaidehyde or appropriate monosaccharides 8a--e with hydrazine hydrate. AMI semi-empirical calculations reveal that the azine system is favoured with a trans geometry and planar conformation for CfN-NfC. All the new compounds were tested for their potential antiviral and antitumor activities.

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