ChemInform Abstract: A New Approach to the Synthesis of Substituted 4-Imidazolidinones as Potential Antiviral and Antitumor Agents.

✍ Scribed by A. I. KHODAIR; P. BERTRAND

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 36 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199831121

✦ Synopsis

A New Approach to the Synthesis of Substituted 4-Imidazolidinones as Potential Antiviral and Antitumor Agents.

-The successful synthesis, conformational analysis and biological testing of unreported series of (III) and polyhydroxylalkylidenehydrazono-substituted title compounds such as (VI) and type (IX) are reported. The latter are of interest since combination of an imidazolinone with a hydrophilic moiety such as glycoside, a better water solubility and improved selectivity toward cancer cells are anticipated. For antiviral activities all new compounds are tested and found to be inactive. For antitumor activities 20 glycoside-substituted derivatives were screened. Only (VIc) and (VId) showed enough activity to be further examined in additional systems. -(KHODAIR, A.