## Abstract The influence of interleukin 2 (IL2) on the cytotoxic activity of lymphocytes from patients with melanoma against autologous and a variety of allogeneic melanoma cells was studied. IL2 was produced from blood lymphocytes cultured for 24 h with phytohaemagglutinin (PHA) and purified by m
Cytotoxicity of lymphocytes from melanoma patients against autologous tumor cells and its potentiationin vitro
β Scribed by S. N. Bykovskaya; M. S. Iobadze; T. A. Kupriyanova; L. V. Demidov
- Publisher
- Springer US
- Year
- 1987
- Tongue
- English
- Weight
- 278 KB
- Volume
- 103
- Category
- Article
- ISSN
- 0007-4888
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Human autologous tumor-specific T-helper 2 (Th2) cells were investigated in melanoma tumor-infiltrating lymphocytes FILS). Both a CD4+ T-cell line and its 5 potential T-cell clones established from TlLs of a patient with metastatic melanoma produced significant levels of IL-4, IL-6, IL-10 and granul