Cytotoxicity and metabolism of prednimustine, chlorambucil and prednisolone in a Chinese hamster cell line
β Scribed by Beryl Hartley-Asp; Per Olov Gunnarsson; Jan Liljekvist
- Book ID
- 104686136
- Publisher
- Springer
- Year
- 1986
- Tongue
- English
- Weight
- 535 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0344-5704
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A strong teratogen-6-aminonicotinamide (6-AN)-was tested for its ability to induce cytotoxicity and mutagenicity in Chinese hamster ovary (CHO) cells. Tests were performed in the presence and absence of a metabolic activation system (S-9 mix). Cytotoxicity was evaluated in CHO cells by the total pro
## Abstract Viability, DNA synthesis and mitosis have been followed in the temperature sensitive Chinese hamster cell mutant K12 under permissive and nonβpermissive conditions. On incubation at 40Β°C cells retained their ability to form colonies at 33Β°C for 15 to 20 hours, but viability was lost gra