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Metabolism and action of neplanocin A in Chinese hamster ovary cells

โœ Scribed by Priscilla P. Saunders; Mei-Tao Tan; Roland K. Robins

Book ID
115778464
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
465 KB
Volume
34
Category
Article
ISSN
0006-2952

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## Abstract To determine if Chinese Hamster Ovary (CHO) cells in culture are able to metabolize steroids, CHO cells were incubated in defined medium with [^14^C]pregnenolone. As shown, [^14^C]pregnenolone is metabolized to progesterone and other ฮด^5^3ฮฒ steroids; this steroidogenic response is appre