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Cytotoxic Isoprenylated Flavonoids from the Roots of Sophora flavescens

✍ Scribed by Peilan Ding; Daofeng Chen; Kenneth F. Bastow; Alexander K. Nyarko; Xihong Wang; Kuo-Hsiung Lee

Publisher
John Wiley and Sons
Year
2004
Tongue
German
Weight
135 KB
Volume
87
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Three new flavonoids, which are isoprenylated by fused 2,2‐dimethyl‐3,4‐dihydro‐2__H__‐pyran moieties, were isolated from the roots of Sophora flavescens and named flavenochromanes A–C (1–3). Their structures were elucidated by spectroscopic methods, including 2D‐NMR techniques. Flavenochromane C (3) showed strong cytotoxic activity against A549 (lung carcinoma), 1A9 (ovarian carcinoma), KB (epidermoid carcinoma of the nasopharynx), and KB‐Vin (drug‐resistant variant KB) cell lines with IC~50~ values ≤1.7 μM, and significant activity against the MCF‐7 (breast adenocarcinoma) cell line with an IC~50~ value of 3.6 μM. Flavenochromane B (2) displayed slightly lower inhibitory effects (IC~50~ 3.2–6.9 μM) as compared with 3.

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